Reaktion #5959

Reaktionsgleichung

Compound ( i )

4-(2-Carbomethoxyphenyl)benzylamine

compound ( b )

(E)-5-Carbethoxymethylidene-3,3-dimethylvalerolactone

→

title compound

6-Carbethoxymethyliden-1-[4-(2-carbomethoxyphenyl)benzyl]-4,4-dimethylpiperidin-2-one

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 5 hours
2. 2
   SonstigeThe toluene is removed in vacuo
3. 3
   Sonstigethe residue is chromatographed on silica gel

Vorschrift

Compound (i) of Example 9 (1.2 g, 0.005 mole) and compound (b) of Example 2 (1.1 g, 0.005 mole) are combined in toluene (50 mL) and refluxed for 5 hours. The toluene is removed in vacuo and the residue is chromatographed on silica gel using hexane/ethyl acetate as the mobile phase. The title compound is isolated as a colorless oil (1.2 g, 52%). Mass Spec. (DCI) m/z 436 (M+H). Analysis--calc'd for C26H29NO5 : C, 70.96; H, 6.76; N, 3.18; found: C, 70.76; H, 7.11; N, 2.77.

Quelle