Reaktion #59561

Reaktionsgleichung

N-[6-(2-phenylchroman-6-yloxy)pyridin-3-yl]methane sulfonamide

6-[2-(2,4-difluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine

6-[2-(2,4-Difluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine

→

N-{6-[2-(2,4-difluorophenyl)chroman-6-yloxy]pyridin-3-yl}methane sulfonamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was crystallised from a mixture of methanol and diethyl ether

Vorschrift

N-{6-[2-(2,4-difluorophenyl)chroman-6-yloxy]pyridin-3-yl}methane sulfonamide was prepared as described for N-[6-(2-phenylchroman-6-yloxy)pyridin-3-yl]methane sulfonamide in Example 46 starting from 100 mg of 6-[2-(2,4-difluorophenyl)chroman-6-yloxy]-pyridin-3-ylamine (Example 70). The product was crystallised from a mixture of methanol and diethyl ether. 1H NMR (400 MHz, d6-DMSO) δ: 9.67 (s, 1H), 7.99 (d, 1H, J 2.8 Hz), 7.67 (dd, 1H, J 8.8, 2.8 Hz), 7.60 (m, 1H), 7.30 (m, 1H), 7.16 (m, 1H), 6.98 (d, 1H, J 8.8 Hz), 6.92-6.86 (m, 3H), 5.31 (dd, 1H, J 10.3, 2.3 Hz), 3.01 (m, 1H), 2.98 (s, 3H), 2.76 (m, 1H), 2.16 (m, 1H), 2.06 (m, 1H).

Quelle