Reaktion #59542

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(2,5-difluorophenyl)chroman-4,6-diol

→

2-(2,5-Difluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified on preparative

Vorschrift

2-(2,5-Difluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 200 mg of 2-(2,5-difluorophenyl)chroman-4,6-diol (Example 14(b)). The product was purified on preparative TLC-plate covered with silica gel using toluene-ethyl acetate (4:1) as an eluant. 1H NMR (400 MHz, CDCl3) δ: 9.03 (d, 1H, J 2.8 Hz), 8.50 (dd, 1H, J 9.1, 2.8 Hz), 7-36-7.33 (m, 2H), 7.08-6.95 (m, 5H), 5.50 (d, 1H, J 11.1 Hz), 5.09 (m, 1H), 2.53 (m, 1H), 2.05 (m, 1H).

Quelle