Reaktion #59541

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(2-fluorophenyl)chroman-4,6-diol

→

2-(2-Fluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was recrystallised from a mixture of 2-propanol and acetone

Vorschrift

2-(2-Fluorophenyl)-6-(5-nitropyridin-2-yloxy)chroman-4-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 315 mg of 2-(2-fluorophenyl)chroman-4,6-diol (Example 19(b)). The product was recrystallised from a mixture of 2-propanol and acetone. 1H NMR (400 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.9 Hz), 8.61 (dd, 1H, J 9.1, 2.9 Hz), 7.61 (m, 1H), 7.43 (m, 1H), 7.31-7.24 (m, 3H), 7.23 (d, 1H, J 9.1 Hz), 7.02 (dd, 1H, J 8.7, 3.1 Hz), 6.89 (d, 1H, J 8.7 Hz), 5.69 (d, 1H, J 6.3 Hz), 5.55 (d, 1H, J 11.9 Hz), 5.00 (m, 1H), 2.33 (m, 1H), 2.07 (m, 1H).

Quelle