Reaktion #595376

Reaktionsgleichung

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

Ausbeute 97.4%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter completion the reaction mixture was concentrated under reduced pressure
2. 2
   Sonstigethe product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

Vorschrift

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

Quelle