Reaktion #595353

Reaktionsgleichung

compound

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

thionyl chloride

→

Methyl 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole-5-carboxylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe excess thionyl chloride is removed under reduced pressure
2. 2
   WaschenThe mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   TrocknenThe organic phase is dried over magnesium sulfate
4. 4
   Sonstigethe solvent is removed under reduced pressure
5. 5
   SonstigeThe product obtained
6. 6
   Sonstigeis used without further purification in the subsequent reactions

Vorschrift

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

Quelle