Reaktion #595352

Reaktionsgleichung

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted three times with in each case 10 ml of diethyl ether
2. 2
   TrocknenThe combined organic phases are dried over magnesium sulfate
3. 3
   Sonstigethe solvent is removed on a rotary evaporator
4. 4
   SonstigeThe product obtained
5. 5
   Sonstigeis used without further purification in the subsequent reaction

Vorschrift

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

Quelle