Reaktion #595333

Reaktionsgleichung

3-fluoro-4-hydroxybenzaldehyde

2-bromoethanol

potassium carbonate

→

3-Fluoro-4-(2-hydroxyethoxy)benzaldehyde

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is then filtered
2. 2
   Sonstigethe filtrate is freed from the solvent on a rotary evaporator
3. 3
   workup.ADDITION20 ml of sat. aqueous sodium bicarbonate solution are added
4. 4
   SonstigeThe phases are separated
5. 5
   Trocknenthe organic phase is dried over magnesium sulfate
6. 6
   SonstigeThe solvent is removed on a rotary evaporator
7. 7
   SonstigeThe product obtained
8. 8
   Sonstigeis used without further purification in the subsequent reaction

Vorschrift

5.00 g (35.69 mmol) of 3-fluoro-4-hydroxybenzaldehyde are dissolved in 50 ml of dry DMF. 5.35 g (42.82 mmol) of 2-bromoethanol and 19.73 g (142.74 mmol) of potassium carbonate are added. The reaction mixture is stirred at 150° C. for 10 h. The mixture is then filtered, and the filtrate is freed from the solvent on a rotary evaporator. The residue is taken up in 30 ml of ethyl acetate, and 20 ml of sat. aqueous sodium bicarbonate solution are added. The phases are separated and the organic phase is dried over magnesium sulfate. The solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

Quelle