Reaktion #595321

Reaktionsgleichung

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

Ausbeute 71.0%

Butyl cyclopropanesulfonate

Ausbeute 71.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was slowly warmed at room temperature
2. 2
   SonstigeThe solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   WaschenThe organic phase was washed with water, brine
5. 5
   Trocknendried (MgSO4)
6. 6
   Einengenconcentrated

Vorschrift

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

Quelle