Reaktion #59488

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(2-fluorophenyl)chroman-6-ol

→

2-[2-(2-Fluorophenyl)chroman-6-yloxy]-5-nitropyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by column chromatography

Vorschrift

2-[2-(2-Fluorophenyl)chroman-6-yloxy]-5-nitropyridine was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 390 mg of 2-(2-fluorophenyl)chroman-6-ol. The product was purified by column chromatography using heptane-ethyl acetate (4:1) as an eluant. 1H NMR (400 MHz, CDCl3) δ: 9.04 (d, 1H, J 2.8 Hz), 8.60 (dd, 1H, J 9.1, 2.8 Hz), 7.56 (m, 1H), 7.43 (m, 1H), 7.30-7.22 (m, 2H), 7.20 (d, 1H, J 9.1 Hz), 7.02 (d, 1H, J 2.8 Hz), 6.98 (dd, 1H, J 8.7, 2.8 Hz), 6.91 (d, 1H, J 8.7 Hz), 5.37 (dd, 1H, J 10.4, 2.3 Hz), 3.04 (ddd, 1H, J −17.0, 11.5, 6.0 Hz), 2.82 (ddd, 1H, J −17.0, 5.1, 2.8 Hz), 2.18 (m, 1H), 2.08 (m, 1H).

Quelle