Reaktion #59481

Reaktionsgleichung

2-(3-fluorophenyl)-6-hydroxychroman-4-one

2,5-dihydroxypropiophenone

benzaldehyde

→

6-Hydroxy-3-methyl-2-phenylchroman-4-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by column chromatography

Vorschrift

6-Hydroxy-3-methyl-2-phenylchroman-4-one was prepared as described for 2-(3-fluorophenyl)-6-hydroxychroman-4-one in Example 9(a) starting from 2.0 g of 2,5-dihydroxypropiophenone and 1.63 ml of benzaldehyde. The product was purified by column chromatography using heptane-ethyl acetate (3:1) as an eluant. 1H NMR (300 MHz, d6-DMSO) δ: 9.37 (s, 1H), 7.53 (m, 2H), 7.47-7.39 (m, 3H), 7.13 (d, 1H, J 3.1 Hz), 7.02 (dd, 1H, J 8.9, 3.1 Hz), 6.89(d, 1H, J 8.9 Hz), 5.17 (d, 1H, J 12.3), 3.18 (dq, 1H, J 12.3, 6.9 Hz), 0.84 (d, 3H, J 6.9 Hz).

Quelle