Reaktion #59472

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-(2,5-difluorophenyl)chroman-6-ol

→

2-[2-(2,5-Difluorophenyl)chroman-6-yloxy]-5-nitropyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was recrystallised from 2-propanol

Vorschrift

2-[2-(2,5-Difluorophenyl)chroman-6-yloxy]-5-nitropyridine was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 100 mg of 2-(2,5-difluorophenyl)chroman-6-ol. The product was recrystallised from 2-propanol. 1H NMR (400 MHz, CDCl3) δ: 9.07 (dd, 1H, J 2.8, 0.4 Hz), 8.47 (dd, 1H, J 9.1, 2.8 Hz), 7.26 (m, 1H), 7.05-6.91 (m, 6H), 5.35 (dd, 1H, J 10.3, 1.5 Hz), 3.04 (ddd, 1H, J −16.9, 11.7, 6.0 Hz), 2.82 (ddd, 1H, J −16.9, 5.2, 3.0 Hz), 2.29 (m, 1H), 2.01 (m, 1H).

Quelle