Reaktion #59461

Reaktionsgleichung

2-(3-fluorophenyl)-6-hydroxychroman-4-one

2′,5′-dihydroxyacetophenone

3-chlorobenzaldehyde

→

2-(3-Chlorophenyl)-6-hydroxychroman-4-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was recrystallised from acetic acid

Vorschrift

2-(3-Chlorophenyl)-6-hydroxychroman-4-one was prepared as described for 2-(3-fluorophenyl)-6-hydroxychroman-4-one in Example 9(a) starting from 2.0 g of 2′,5′-dihydroxyacetophenone and 1.85 g of 3-chlorobenzaldehyde. The product was recrystallised from acetic acid. 1H NMR (400 MHz, d6-DMSO) δ: 9.47 (s, 1H), 7.62 (s, 1H), 7.51-7.45 (m, 3H), 7.12 (d, 1H, J 3.0 Hz), 7.05 (dd, 1H, J 8.8, 3.0 Hz), 6.98 (d, 1H, J 8.8 Hz), 5.58 (dd, 1H, J 13.1, 2.9 Hz), 3.18 (dd, 1H, J −16.9, 13.1 Hz), 2.81 (dd, 1H, J −16.9, 2.9 Hz).

Quelle