Reaktion #59456

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

2-phenylchroman-7-ol

→

5-Nitro-2-(2-phenylchroman-7-yloxy)pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified on preparative

Vorschrift

5-Nitro-2-(2-phenylchroman-7-yloxy)pyridine was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(b) starting from 115 mg of 2-phenylchroman-7-ol. The product was purified on preparative TLC-plate covered with silica gel using toluene-ethyl acetate (15:1) as an eluant. 1H NMR (400 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.8 Hz), 8.60 (dd, 1H, J 9.1, 2.8 Hz), 7.46-7.32 (m, 5H), 7.22 (d, 1H, J 9.1 Hz), 7.20 (d, 1H, J 8.9 Hz), 6.72 (dd, 1H, J 8.9, 2.3 Hz), 6.72 (d, 1H, J 2.3 Hz), 5.16 (dd, 1H, J 10.1, 2.1 Hz), 2.97 (ddd, 1H, J −16.7, 11.3, 5.9 Hz), 2.77 (ddd, 1H, J −16.7, 8.1, 4.5 Hz), 2.20 (m, 1H), 2.02 (m, 1H).

Quelle