Reaktion #59455

Reaktionsgleichung

5-nitro-2-(2-phenylchroman-6-yloxy)pyridine

7-hydroxy-flavanone

→

2-Phenyl-chroman-7-ol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by column chromatography

Vorschrift

2-Phenyl-chroman-7-ol was prepared as described for 5-nitro-2-(2-phenylchroman-6-yloxy)pyridine in Example 1(a) starting from 1.0 g of 7-hydroxy-flavanone. The product was purified by column chromatography using heptane-ethyl acetate (2:1) as an eluant. 1H NMR (400 MHz, CD3OD) δ: 7.41-7.28 (m, 5H), 6.86 (d, 1H, J 8.2 Hz), 6.32 (dd, 1H, J 8.2, 2.4 Hz), 6.29 (d, 1H, J 2.4 Hz), 5.00 (dd, 1H, J 9.9, 2.4 Hz), 2.84 (m, 1H), 2.64 (m, 1H), 2.15 (m, 1H), 1.99 (m, 1H).

Quelle