Reaktion #593771

Reaktionsgleichung

5-bromo-2,3-diaminopyridine

4-(2-diethylamino-ethoxy)benzaldehyde

→

crude product

{2-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)-phenoxy]-ethyl}-diethyl-amine

Lösungsmittel

nitrobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by vacuum distillation
2. 2
   workup.ADDITIONThe residue was dispersed in ethyl acetate

Vorschrift

3.31 g 5-bromo-2,3-diaminopyridine and 3.90 g 4-(2-diethylamino-ethoxy)benzaldehyde in 120 ml nitrobenzene were heated to 140-150° C. for 24 hrs. The solvent was removed by vacuum distillation. The residue was dispersed in ethyl acetate and the crude product was isolated by filtration and washed thoroughly with more ethyl acetate.

Quelle