Reaktion #59305

ord-694d5e9e76274c358010101112ac021e

Reaktionsgleichung

COCCN1C(=O)[C@@H](NC(=O)[C@](C)(F)C(=O)O)c2ccccc2-c2ccccc21
(S)-2-fluoro-N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methyl-malonamic acid
NCC(F)(F)C(F)(F)F
2,2,3,3,3-pentafluoropropylamine
→
COCCN1C(=O)[C@@H](NC(=O)[C@](C)(F)C(=O)NCC(F)(F)C(F)(F)F)c2ccccc2-c2ccccc21
title compound
COCCN1C(=O)[C@@H](NC(=O)[C@](C)(F)C(=O)NCC(F)(F)C(F)(F)F)c2ccccc2-c2ccccc21
(R)-2-Fluoro-N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methyl-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide

Edukte

COCCN1C(=O)[C@@H](NC(=O)[C@](C)(F)C(=O)O)c2ccccc2-c2ccccc21
(S)-2-fluoro-N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methyl-malonamic acid
NCC(F)(F)C(F)(F)F
2,2,3,3,3-pentafluoropropylamine
—
solid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using (S)-2-fluoro-N—[(S)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-methyl-malonamic acid and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 1c. White solid (71%). MS: m/e=532(M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07425551B2uspto-grants-2008_09