Reaktion #59294

ord-d080ef81ff0143b4ba953a18dd482243

Reaktionsgleichung

N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
(S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one
CCOC(=O)[C@](C)(F)C(=O)O
(R)-2-fluoro-2-methyl-malonic acid monoethyl ester
→
CCOC(=O)[C@](C)(F)C(=O)N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
title compound
CCOC(=O)[C@](C)(F)C(=O)N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
(R)—N—[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid ethyl ester

Edukte

N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
(S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one
CCOC(=O)[C@](C)(F)C(=O)O
(R)-2-fluoro-2-methyl-malonic acid monoethyl ester
—
oil

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and (R)-2-fluoro-2-methyl-malonic acid monoethyl ester, the title compound was prepared in the same manner as described for example 1c. Light yellow oil (96%). MS: m/e=505(M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07425551B2uspto-grants-2008_09