Reaktion #59288

ord-37cf8da127ef4f3b892201f90b8210c9

Reaktionsgleichung

N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
(S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one
CCOC(=O)C(OCC)C(=O)O
2-ethoxy-malonic acid monoethyl ester
→
CCOC(=O)C(OCC)C(=O)N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
title compound
CCOC(=O)C(OCC)C(=O)N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
N—[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-malonamic acid ethyl ester

Edukte

N[C@@H]1C(=O)N(CCOCc2ccccc2)c2ccccc2-c2ccccc21
(S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one
CCOC(=O)C(OCC)C(=O)O
2-ethoxy-malonic acid monoethyl ester
—
oil

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using (S)-7-amino-5-(2-benzyloxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and 2-ethoxy-malonic acid monoethyl ester, the title compound was prepared in the same manner as described for example 1c. Colorless oil (94%). MS: m/e=517(M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07425551B2uspto-grants-2008_09