Reaktion #59232

Reaktionsgleichung

resorcinol

sodium methoxide

3-bromoanisole

→

3-(3′-methoxyphenyloxy)phenol

Lösungsmittel

pyridine

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a round-bottomed flask fitted with a Vigreux column
2. 2
   SonstigeMethanol is then removed from the reaction mixture by distillation
3. 3
   SonstigeThe reflux divider is then closed
4. 4
   Temperaturunder reflux for 6 hours
5. 5
   workup.DISTILLATIONPyridine is then distilled off via the
6. 6
   Temperaturopened reflux divider
7. 7
   Sonstigerises to 150° C
8. 8
   Temperaturto cool
9. 9
   workup.STIRRINGthe residue is stirred into 250 ml of semi-concentrated hydrochloric acid
10. 10
    ExtraktionThe mixture is extracted with 300 ml of toluene
11. 11
    WaschenThe organic phase is washed first with semi-concentrated hydrochloric acid
12. 12
    Extraktionextracted with a diethyl ether/toluene mixture (1:1)
13. 13
    SonstigeAfter removal of the solvent, 65.5 g of a brown oil
14. 14
    Sonstigeare obtained

Vorschrift

In a round-bottomed flask fitted with a Vigreux column, a reflux divider and a condenser, 77.08 g (0.70 mol.) of resorcinol are dissolved, under argon, in 250 ml of dry pyridine. 84.3 g of sodium methoxide solution in methanol (30% solution) are added dropwise to the reaction mixture, with stirring. Methanol is then removed from the reaction mixture by distillation. The reflux divider is then closed and 261.9 g (1.40 mol.) of 3-bromoanisole are added dropwise. 3.5 g (0.04 mol.) of CuCl are also added. The mixture is allowed to boil under reflux for 6 hours. Pyridine is then distilled off via the opened reflux divider, during which the sump temperature rises to 150° C. The mixture is then allowed to cool and the residue is stirred into 250 ml of semi-concentrated hydrochloric acid. The mixture is extracted with 300 ml of toluene. The organic phase is washed first with semi-concentrated hydrochloric acid and then a further two times with NaOH solution (10%). The combined alkaline phases are acidified with dilute HCl and extracted with a diethyl ether/toluene mixture (1:1). After removal of the solvent, 65.5 g of a brown oil are obtained.

Quelle