Reaktion #592255
ord-e290cce8ef914ea8a3ff203da847e888
Reaktionsgleichung
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide
sodium trimethylsilanolate
→
title compound
Ausbeute 27.0%
6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid
Ausbeute 27.0%
Edukte
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1Einengenthe mixture was concentrated in vacuo
- 2Sonstigepurified by prep
Vorschrift
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.