Reaktion #592155

ord-7d4063029c984af581ff93321a7a899d

Reaktionsgleichung

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNc1c(NCCCOCCOCCOCCCNC(=O)CCC(NC(=O)c2ccc(NCc3cnc4nc(N)[nH]c(=O)c4n3)cc2)C(=O)O)c(=O)c1=O
18-[(4-{[(2-amino-4-oxo-3,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]-1-({2-[(39,39-dimethyl-37-oxo-3,6,9,12,15,18,21,24,27,30,33,38-dodecaoxa-36-azatetracont-1-yl)amino]-3,4-dioxo-1-cyclobuten-1-yl}amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid
→
NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNc1c(NCCCOCCOCCOCCCNC(=O)CCC(NC(=O)c2ccc(NCc3cnc4nc(N)[nH]c(=O)c4n3)cc2)C(=O)O)c(=O)c1=O
18-[(4-{[(2-amino-4-oxo-3,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]-1-({2-[(35-amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacont-1-yl)amino]-3,4-dioxo-1-cyclobuten-1-yl}amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Edukte

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNc1c(NCCCOCCOCCOCCCNC(=O)CCC(NC(=O)c2ccc(NCc3cnc4nc(N)[nH]c(=O)c4n3)cc2)C(=O)O)c(=O)c1=O
18-[(4-{[(2-amino-4-oxo-3,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]-1-({2-[(39,39-dimethyl-37-oxo-3,6,9,12,15,18,21,24,27,30,33,38-dodecaoxa-36-azatetracont-1-yl)amino]-3,4-dioxo-1-cyclobuten-1-yl}amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Reagenzien

Keine

Lösungsmittel

O=C(O)C(F)(F)F
trifluoroacetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

0.3 g of 18-[(4-{[(2-amino-4-oxo-3,4-dihydro-6-pteridinyl)methyl]amino}benzoyl)amino]-1-({2-[(39,39-dimethyl-37-oxo-3,6,9,12,15,18,21,24,27,30,33,38-dodecaoxa-36-azatetracont-1-yl)amino]-3,4-dioxo-1-cyclobuten-1-yl}amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid is solubilized in 0.3 ml of trifluoroacetic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07780953B2uspto-grants-2010_08