Reaktion #591597

Reaktionsgleichung

(4-ethynylphenyl)acetonitrile

1-bromo-2-chloro-ethane

NaOH water

→

desired product

Ausbeute 92.7%

1-(4-ethynylphenyl)cyclopropanecarbonitrile

Ausbeute 92.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe product was extracted with EtOAc
2. 2
   Waschenthe combined organic phases were washed with water and brine successively
3. 3
   Trocknendried over Na2SO4
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in-vacuo

Vorschrift

A mixture of (4-ethynylphenyl)acetonitrile (1.0 g, 0.0071 mol), 1-bromo-2-chloro-ethane (1200 μL, 0.014 mol), benzyltriethylammonium chloride (0.1 g, 0.0004 mol) and 1 ml of 50% NaOH water (w/v) was heated at 50° C. for 4 hours. The product was extracted with EtOAc and the combined organic phases were washed with water and brine successively, dried over Na2SO4, filtered, and concentrated in-vacuo to afford 1.1 g of the desired product, which was used in the following step without further purification.

Quelle