Reaktion #591515

Reaktionsgleichung

1,2-ethanediol

{4-[(trifluoromethyl)thio]phenyl}acetonitrile

1-bromo-2-chloro-ethane

NaOH water

→

solid

1-{4-[(trifluoromethyl)thio]phenyl}cyclopropanecarboxylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas kept at 50° C.

Vorschrift

A mixture of {4-[(trifluoromethyl)thio]phenyl}acetonitrile (1.15 g, 0.00529 mol), 1-bromo-2-chloro-ethane, (880 μL, 0.010 mol), benzyltriethyl ammonium chloride (70 mg, 0.0003 mol) and 1.5 ml of 50% NaOH-water (w/w) solution was kept at 50° C. with stirring for 3 hours. LCMS data supported that the reaction was complete. To the above solution 1,2-ethanediol (10 mL, 0.2 mol) was added. The mixture was heated at 100° C. overnight. After work-up 1.2 g of solid product was obtained. LC/MS: 387.1 (M+H+).

Quelle