Reaktion #591453

Reaktionsgleichung

Hunig base

1-(4-chlorophenyl)cyclopropanecarboxylic acid

BOP reagent

2-phenylpyrrolidine

→

1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-2-phenylpyrrolidine

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedirectly purified by flash column

Vorschrift

To a solution of 30 mg of 1-(4-chlorophenyl)cyclopropanecarboxylic acid and 81 mg BOP reagent in 0.5 mL methylene chloride wad added 27 mg of 2-phenylpyrrolidine, followed by the addition of 53 ul of Hunig base. The reaction mixture was stirred at r.t. for 2 hours and directly purified by flash column using ethyl/hexane as the eluting solvent to provide the desired 1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-2-phenylpyrrolidine. LCMS (ESI): 326.1 (M+H+).

Quelle