Reaktion #59072

Reaktionsgleichung

3-(tert-butyl)phenylamine

sodium bicarbonate

thiophosgene

→

3-(tert-butyl)benzenisothiocyanate

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas brought to ambient temperature
2. 2
   Einengenconcentrated
3. 3
   Sonstigepartitioned between ethyl acetate and water
4. 4
   TrocknenThe organic layer was dried with sodium bicarbonate and sodium sulfate
5. 5
   Einengenconcentrated

Vorschrift

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

Quelle