Reaktion #59019

Reaktionsgleichung

hydrochloric acid

Trifluoromethanesulfonic anhydride

methyl 4-hydroxy-2-methoxybenzoate

pyridine

→

methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate

Lösungsmittel

ethyl acetate

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 30 min
3. 3
   ExtraktionThe resulting mixture was extracted with ethyl acetate
4. 4
   WaschenThe organic layer was washed with water and brine
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   SonstigeThe solvent was evaporated under reduced pressure

Vorschrift

Trifluoromethanesulfonic anhydride (2.24 mL) was added to an ice-cooled mixture of methyl 4-hydroxy-2-methoxybenzoate (2.02 g) and pyridine (0.14 mL) in methylene chloride (15 mL) with stirring. The mixture was stirred at room temperature for 30 min, and poured into a mixture of hydrochloric acid and ethyl acetate. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate (3.49 g).

Quelle