Reaktion #590027

Reaktionsgleichung

Thionyl chloride

4-bromo-3-hydroxymethyl-1-iodo-benzene

DMF

→

4-Bromo-3-chloromethyl-1-iodo-benzene

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen, the solvent and the excess reagent is removed under reduced pressure
2. 2
   SonstigeThe residue is triturated with methanol
3. 3
   Sonstigedried

Vorschrift

Thionyl chloride (13 mL) is added to a suspension of 4-bromo-3-hydroxymethyl-1-iodo-benzene (47.0 g) in dichloromethane (100 mL) containing DMF (0.1 mL). The mixture is stirred at ambient temperature for 3 h. Then, the solvent and the excess reagent is removed under reduced pressure. The residue is triturated with methanol and dried.

Quelle