Reaktion #58960

Reaktionsgleichung

Hydrochloric acid

ethyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)acrylate

methanol

sodium hydroxide

→

(2E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

Ausbeute 83.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed with water
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated

Vorschrift

To a mixture of ethyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)acrylate (2.5 g), methanol (20 ml) and tetrahydrofuran (20 ml) was added a 2N aqueous sodium hydroxide solution (13.9 ml) and the mixture was stirred at 60° C. for 3 hrs. 1N Hydrochloric acid was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated to give (2E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid (1.75 g, 83%) as an amorphous form.

Quelle