Reaktion #589012

ord-88965aaa5e764a9a987fed00cee01d87

Reaktionsgleichung

CCOC(=O)COc1ccc(NC(C)=O)cc1
(4-Acetylamino-phenoxy)-acetic acid ethyl ester
Cl
Hydrochloric acid
→
Cl.Nc1ccc(OCC(=O)O)cc1
2
Ausbeute 77.6%
Cl.Nc1ccc(OCC(=O)O)cc1
(4-Amino-phenoxy)acetic acid HCl
Ausbeute 77.6%

Edukte

CCOC(=O)COc1ccc(NC(C)=O)cc1
(4-Acetylamino-phenoxy)-acetic acid ethyl ester
Cl
Hydrochloric acid

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
10°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. 2
    Filtrationfiltered hot
  3. 3
    Filtrationfiltered
  4. 4
    Sonstigedried

Vorschrift

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2(250 g, 77.6%) as a wheat colored powder.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07772352B2uspto-grants-2010_08