Reaktion #5890

ord-c1cccb7f4ab14334a9142cd6bd51341b

Reaktionsgleichung

CC1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole
CC(=O)N1CCNCC1
1-acetyl-piperazine
→
CC(=O)N1CCN(C(=S)Nc2cc3sc(C(C)(C)C)nc3cc2N2CCC(C)CC2)CC1
6-[(4-acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole

Edukte

CC1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole
CC(=O)N1CCNCC1
1-acetyl-piperazine

Reagenzien

Keine

Lösungsmittel

ClC(Cl)Cl
chloroform

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe product triturated with petroleum ether

Vorschrift

A solution of 2.0 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole and 0.78 g of 1-acetyl-piperazine in 30 ml of chloroform is stirred for 30 minutes and the product triturated with petroleum ether to obtain 6-[(4-acetyl-piperazin-1-yl)thiocarbonylamino]-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 187°-190°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05246927uspto-grants-1993_09