Reaktion #5885

Reaktionsgleichung

N-tert-butylthiocarbonyl-2,5-dichloro-4-nitroaniline

N-methylpiperazine

water

→

2-tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole

Lösungsmittel

dimethylsulphoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   FiltrationThe solid is filtered
3. 3
   Waschenwashed with water and cold isopropanol

Vorschrift

A solution of 171 g of N-tert-butylthiocarbonyl-2,5-dichloro-4-nitroaniline (described in European patent application No. 85810418.5 published under No. 0175650) and 605 ml of N-methylpiperazine in 1700 ml of dimethylsulphoxide is heated at 140° for 8 hours, cooled and poured into water. The solid is filtered, washed with water and cold isopropanol to yield 2-tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole, melting at 132°-135°.

Quelle