Reaktion #5884

ord-c586dd8d365640deae3890d8575254f9

Reaktionsgleichung

CN1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methyl-piperazin-1-yl)benzothiazole
CN1CCNCC1
4-methylpiperazine
→
CN1CCN(C(=S)Nc2cc3sc(C(C)(C)C)nc3cc2N2CCN(C)CC2)CC1
2-tert-butyl-6[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methyl-piperazin-1-yl)benzothiazole

Edukte

CN1CCN(c2cc3nc(C(C)(C)C)sc3cc2N=C=S)CC1
2-tert-butyl-6-isothiocyanato-5-(4-methyl-piperazin-1-yl)benzothiazole
CN1CCNCC1
4-methylpiperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the procedure described in Example 1 by reaction of 2-tert-butyl-6-isothiocyanato-5-(4-methyl-piperazin-1-yl)benzothiazole with 4-methylpiperazine is obtained 2-tert-butyl-6[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methyl-piperazin-1-yl)benzothiazole, melting at 190°-193°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05246927uspto-grants-1993_09