Reaktion #58818

Reaktionsgleichung

4-aminophenol

butyric acid

DCC

→

4-butyramidophenol

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe contents stirred overnight at room temperature
2. 2
   FiltrationThe reaction mixture is then filtered
3. 3
   Waschenwashed with DCM
4. 4
   EinengenThe filtrate is concentrated
5. 5
   workup.DISSOLUTIONredissolved in methanol
6. 6
   workup.ADDITIONadded with 10% aqueous sodium bicarbonate solution
7. 7
   workup.STIRRINGstirred vigorously until diacylated byproduct

Vorschrift

4-aminophenol (550 mg; 5 mmol) is added to a solution of butyric acid (1.4 mL; 15 mmol) in DCM (20 mL) at room temperature and stirred vigorously. To this solution DCC (2.48 g; 12 mmol) is added followed by DMAP (24 mg) and the contents stirred overnight at room temperature. The reaction mixture is then filtered and washed with DCM. The filtrate is concentrated and redissolved in methanol, added with 10% aqueous sodium bicarbonate solution and stirred vigorously until diacylated byproduct disappeared (as detected by LC-MS) to yield 4-butyramidophenol as the only product. The product was used for further transformation without further purification.

Quelle