Reaktion #5881

Reaktionsgleichung

water

2-tert-butyl-5-chloro-6-nitrobenzothiazole

4-methylpiperidine

potassium carbonate

→

2-tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole

Lösungsmittel

chloroform

dimethylsulphoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   SonstigeThe solid obtained
3. 3
   Filtrationfiltered through a silical gel column
4. 4
   SonstigeThe filtate is evaporated

Vorschrift

A solution of 32,4 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole, (described in European patent application 85810418.5 published under No. 0175650) in 300 ml of dimethylsulphoxide, is stirred and heated at 140° for 6 hours with 12.8 g of 4-methylpiperidine and 35.8 g of anhydrous potassium carbonate, cooled and poured into water. The solid obtained is dissolved in chloroform and filtered through a silical gel column. The filtate is evaporated to give 2-tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole melting at 116°-120°.

Quelle