Reaktion #588070

ord-49e7b332fefd4893821c1fc34710d667

Reaktionsgleichung

Cc1cnn(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4)c3s2)c1
compound 258a
Cc1cnn(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4)c3s2)c1
N-(4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide
Cc1cn[nH]c1
4-methyl-1H-pyrazole
c1cn[nH]c1
1H-pyrazole
→
O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(-n4cccn4)sc23)cc1
title compound 258b
O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(-n4cccn4)sc23)cc1
N-(4-(2-(1H-Pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Edukte

Cc1cnn(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4)c3s2)c1
compound 258a
Cc1cnn(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4)c3s2)c1
N-(4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide
Cc1cn[nH]c1
4-methyl-1H-pyrazole
c1cn[nH]c1
1H-pyrazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedures described above for the synthesis of compound 258a (example 215, scheme 58) but replacing 4-methyl-1H-pyrazole in the step 1 with 1H-pyrazole, title compound 258b was obtained. Characterization of 258b is provided in the table 23.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07772247B2uspto-grants-2010_08