Reaktion #587781

Reaktionsgleichung

Methyl iodide

potassium carbonate

2-chloro-6-fluorophenol

→

title compound

Ausbeute 94.0%

1-Chloro-3-Fluoro-2-Methoxybenzene

Ausbeute 94.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was partitioned between diethyl ether (50 ml) and water (50 ml)
2. 2
   ExtraktionThe organic phase was extracted
3. 3
   Waschenfurther washed with water (2×20 ml)
4. 4
   Trocknenthen dried over sodium sulphate
5. 5
   Einengenconcentrated in vacuo

Vorschrift

Methyl iodide (850 μl, 13.646 mmol) and potassium carbonate (943 mg, 6.824 mmol) were added to 2-chloro-6-fluorophenol (1.0 g, 6.824 mmol) in tetrahydrofuran (10 ml) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was partitioned between diethyl ether (50 ml) and water (50 ml). The organic phase was extracted and further washed with water (2×20 ml) then dried over sodium sulphate and concentrated in vacuo to afford the title compound as a colourless liquid in 94% yield, 1.03 g.

Quelle