Reaktion #5876

Reaktionsgleichung

methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)glycine

acetic acid anhydride

formic acid

→

methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)-N-formylglycine

Ausbeute 78.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture is evaporated in vacuo
2. 2
   WaschenThe organic layer is washed with a sodium hydrogen carbonate solution and water
3. 3
   Sonstigedried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe residue is crystallized from a mixture of 2,2'-oxybispropane and hexane
7. 7
   FiltrationThe product is filtered off
8. 8
   Sonstigedried

Vorschrift

A solution of 17 parts of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)glycine in 60 parts of formic acid and 20 parts of acetic acid anhydride is stirred overnight at room temperature. The reaction mixture is evaporated in vacuo and the residue is taken up in 1,1'-oxybisethane. The organic layer is washed with a sodium hydrogen carbonate solution and water dried, filtered and evaporated. The residue is crystallized from a mixture of 2,2'-oxybispropane and hexane. The product is filtered off and dried, yielding 15 parts (78.7%) of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)-N-formylglycine.

Quelle