Reaktion #58758

Reaktionsgleichung

5-dibromomethyl-pyrazine-2-carboxylic acid methyl ester

ethanol

→

title compound

5-Formyl-pyrazine-2-carboxylic acid methyl ester

Lösungsmittel

THF

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated at 80° C. for 1.25 h
2. 2
   Filtrationwas filtered while hot
3. 3
   EinengenThe filtrate was concentrated

Vorschrift

A solution of 5-dibromomethyl-pyrazine-2-carboxylic acid methyl ester (1.00 g, 3.23 mmol) in a mixture of ethanol (20 mL) and THF (10 mL) was heated to 80° C. A solution of silver nitrate (2.20 g, 12.9 mmol) in H2O (4 mL) was added. The reaction mixture was heated at 80° C. for 1.25 h and was filtered while hot. The filtrate was concentrated to yield the title compound (1.36 g). This material was carried to the next step without purification.

Quelle