Reaktion #58740

Reaktionsgleichung

NaH

3-piperidin-1-yl-propan-1-ol

2-bromo-5-piperidin-1-ylmethyl-pyridine

→

title compound

5-Piperidin-1-ylmethyl-2-(3-piperidin-1-yl-propoxy)-pyridine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter 18 h
2. 2
   Extraktionthe reaction is extracted with ethyl acetate (100 mL)
3. 3
   Waschenwashed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL)
4. 4
   SonstigeThe organic layer is dried
5. 5
   Einengenconcentrated
6. 6
   Sonstigechromatographed on SiO2

Vorschrift

To a suspension of NaH (1.5 mmol) in DMF is added 3-piperidin-1-yl-propan-1-ol (1.1 mmol). After 30 min, 2-bromo-5-piperidin-1-ylmethyl-pyridine (1 mmol) is added to the mixture. After 18 h, the reaction is extracted with ethyl acetate (100 mL) and washed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL). The organic layer is dried, concentrated, and chromatographed on SiO2 to provide the title compound.

Quelle