Reaktion #5868

Reaktionsgleichung

sodium hydroxide

sodium nitrite

nitric acid

1-(2,2-dimethyl-indan-1-yl)-2-mercapto-5-imidazolecarboxylic acid methyl ester

→

1-(2,2-dimethyl-indan-1-yl)-5-imidazolecarboxylic acid methyl ester

Ausbeute 96.7%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionExtracting the aqueous phase with chloroform
2. 2
   Sonstigeevaporating the organic solvent

Vorschrift

2 g of sodium nitrite and 17.4 ml of nitric acid are solved in 140 ml of deionisized water. Within 20 min. 28 g of 1-(2,2-dimethyl-indan-1-yl)-2-mercapto-5-imidazolecarboxylic acid methyl ester are added portionwise at a temperature between 30° C. and 50° C. The reaction mixture is treated with conc. aqueous sodium hydroxide solution. Extracting the aqueous phase with chloroform, and evaporating the organic solvent yields 24.2 g of 1-(2,2-dimethyl-indan-1-yl)-5-imidazolecarboxylic acid methyl ester as a colourless product (m.p. 96°-97° C.).

Quelle