Reaktion #58671

Reaktionsgleichung

1-(4-pyridyl)cyclopentanecarboxylic acid, benzyl ester

→

title compound

1-(4-Pyridyl)cyclopentanecarboxylic acid

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was degassed
2. 2
   workup.ADDITIONfilled with hydrogen using a balloon
3. 3
   Filtrationthe reaction mixture was filtered through Celite
4. 4
   Einengenthe filtrate was concentrated to dryness

Vorschrift

To a solution of 1-(4-pyridyl)cyclopentanecarboxylic acid, benzyl ester (Step C, 0.36 g, 1.3 mmol) in methanol (10 mL) was added palladium on carbon (10% w/w, 75 mg). The mixture was degassed and filled with hydrogen using a balloon. After stirring overnight, the reaction mixture was filtered through Celite, and the filtrate was concentrated to dryness to afford the title compound. LC-MS: m/e 192 (M+H)+ (0.8 min).

Quelle