Reaktion #586442

Reaktionsgleichung

methyl thiosalicylate

cyanopyrazine

triethylamine

→

titled compound

Ausbeute 22.4%

2-Pyrazinyl-4H-1,3-benzothiazine-4-one

Ausbeute 22.4%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   Sonstigethe residue was recrystallized from dioxane-hexane

Vorschrift

A mixture of methyl thiosalicylate (1.68 g, 10.0 mmol), cyanopyrazine (1.06 g, 10.1 mmol), triethylamine (2.10 ml, 15.1 mmol) and toluene (10.0 ml) was refluxed at 120° C. for 8 hrs. The solvent was evaporated and the residue was recrystallized from dioxane-hexane to give the titled compound (0.54 g, 22%) as crystals.

Quelle