Reaktion #58635

Reaktionsgleichung

ether

3-bromophenylacetone

methyl iodide

cesium carbonate

→

title compound

3-(3-Bromophenyl)-2-butanone

Lösungsmittel

water

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic layer was separated
2. 2
   Extraktionthe aqueous layer extracted with ether
3. 3
   TrocknenThe combined organic extracts were dried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated to dryness

Vorschrift

To a solution of 3-bromophenylacetone (4.7 g, 22 mmol) in acetonitrile (100 mL) was added methyl iodide (1.4 mL, 22 mmol) and cesium carbonate (14 g, 44 mmol). After stirring at room temperature for 17 h, the reaction mixture was poured into ether (100 mL) and water (100 mL). The organic layer was separated and the aqueous layer extracted with ether. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated to dryness to give the title compound.

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