Reaktion #586113

Reaktionsgleichung

N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide

→

N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide

Ausbeute 85.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a flask equipped with a magnetic stirring bar
2. 2
   SonstigeNitrogen is bubbled through the solution and 10% Pd on charcoal
3. 3
   workup.ADDITIONis added
4. 4
   SonstigeAfter flushing with nitrogen
5. 5
   SonstigeThe suspension is flushed with nitrogen
6. 6
   Filtrationfiltered
7. 7
   Waschenrinsed over Celite
8. 8
   EinengenThe filtrate is concentrated under vacuum

Vorschrift

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide (85%).

Quelle