Reaktion #585707

ord-6a5955a9d22a4bc6a5bf64c2fdf9165d

Reaktionsgleichung

CC(C)(C)OC(=O)Nc1ccc(Cl)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1
{4-chloro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA
→
O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(Cl)cc2N1
title compound
O=C1CC(c2cccc(-c3cccnc3)c2)=Nc2ccc(Cl)cc2N1
8-Chloro-4-(3-pyridin-3-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Edukte

CC(C)(C)OC(=O)Nc1ccc(Cl)cc1NC(=O)CC(=O)c1cccc(-c2cccnc2)c1
{4-chloro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA

Reagenzien

Keine

Lösungsmittel

ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from {4-chloro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester (Example M25) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (84 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06949542B2uspto-grants-2005_09