Reaktion #585704

ord-5defceea3692403ea16bf905ea0d56de

Reaktionsgleichung

Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(Cl)c(F)cc3NC(=O)OC(C)(C)C)c2)cn1
(4-chloro-5-fluoro-2-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA
→
Cc1ccc(-c2cccc(C3=Nc4cc(F)c(Cl)cc4NC(=O)C3)c2)cn1
title compound
Cc1ccc(-c2cccc(C3=Nc4cc(F)c(Cl)cc4NC(=O)C3)c2)cn1
8-Chloro-7-fluoro-4-[3-(6-methyl-pyridin-3-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Edukte

Cc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(Cl)c(F)cc3NC(=O)OC(C)(C)C)c2)cn1
(4-chloro-5-fluoro-2-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester
O=C(O)C(F)(F)F
TFA

Reagenzien

Keine

Lösungsmittel

ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from (4-chloro-5-fluoro-2-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M20) (241 mg, 0.48 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (124 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06949542B2uspto-grants-2005_09