Reaktion #585423

ord-2d94189f34794edba7324aec2bd72910

Reaktionsgleichung

COC(=O)c1cccc(-c2ccnc(COC3CCCCO3)c2)c1
(RS)-3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-benzoic acid methyl ester
CC(=O)OC(C)(C)C
tert-butyl acetate
→
CC(C)(C)OC(=O)CC(=O)c1cccc(-c2ccnc(COC3CCCCO3)c2)c1
title compound
CC(C)(C)OC(=O)CC(=O)c1cccc(-c2ccnc(COC3CCCCO3)c2)c1
(RS)-3-Oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic acid tert-butyl ester

Edukte

COC(=O)c1cccc(-c2ccnc(COC3CCCCO3)c2)c1
(RS)-3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-benzoic acid methyl ester
CC(=O)OC(C)(C)C
tert-butyl acetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Reaction of (RS)-3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-benzoic acid methyl ester with tert-butyl acetate according to general procedure K (method d; example K8) yielded the title compound as a light yellow oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06949542B2uspto-grants-2005_09