Reaktion #58513

Reaktionsgleichung

5-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

methanol

→

5-[1-(4-amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Sonstigethe solvent was evaporated

Vorschrift

A mixture of 500 mg (1.497 mmol) 5-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester, 200 mg palladium on charcoal (10%), 10 ml methanol and 5 ml THF was hydrogenated at 30 mbar for 3 h. The catalyst was filtered off, the solvent was evaporated to give 5-[1-(4-amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester.

Quelle