Reaktion #58488

Reaktionsgleichung

2-amino-6-(1-methylpiperidin-4-ylcarbonyl)pyridine

2-trifluoromethoxybenzoyl chloride

→

title compound

Ausbeute 76.0%

2-Trifluoromethoxy-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide mono-hydrochloride salt

Ausbeute 76.0%

Lösungsmittel

1,4-Dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheat the mixture
2. 2
   Temperaturat reflux
3. 3
   WaschenLoad on an SCX column (10 g), wash with methanol
4. 4
   Waschenelute with 2M ammonia/methanol
5. 5
   EinengenConcentrate the eluent

Vorschrift

Combine 2-amino-6-(1-methylpiperidin-4-ylcarbonyl)pyridine (0.18 g, 0.84 mmol), 2-trifluoromethoxybenzoyl chloride (0.23 g, 1.0 mmol) and 1,4-Dioxane (5 mL). Stir and heat the mixture at reflux. After 3 hr., cool the reaction mixture to ambient temperature. Load on an SCX column (10 g), wash with methanol, and elute with 2M ammonia/methanol. Concentrate the eluent to obtain the free base of the title compound (0.26 g, 76%). Dissolve the free base in methanol (10 mL) and treat with ammonium chloride (0.032 g). Concentrate and dry under vacuum to obtain the title compound. HRMS Obs. m/z 408.1517, Calc. m/z 408.1535; m.p. 155-160° C.

Quelle